Actin gamma 1 pseudogene

The actin, gamma 1 pseudogene (ENSG00000249878, LOC643307) is a non-protein-coding sequence in the human genome that is homologous to ACTG1, the gene encoding cytoplasmic actin gamma 1. Unlike the protein-coding ACTG1 gene, this pseudogene does not produce a functional actin protein and has no established cellular roles. Pseudogenes often arise from gene duplication or retrotransposition events, and while they may sometimes serve regulatory functions (such as generation of non-coding RNAs), there is no evidence of such a role for this locus. ACTG1 (not this pseudogene) is the gene relevant for hearing, cytoskeletal disorders, and certain cancers[1][2][3]. This pseudogene should not be mistaken for ACTG1, the protein-coding gene with clinical and therapeutic relevance. Key distinction: If you are seeking information about the cytoskeletal protein or a pharmaceutically relevant target, you should refer to the protein-coding gene ACTG1 (Ensembl: ENSG00000184009), not this pseudogene[2][3]. The current entry is not a valid therapeutic or functional molecular target.

Other names

LOC643307actin, gamma 1 pseudogeneACTG1P