Actin-like protein 6A (ACTL6A)

Actin-like protein 6A (ACTL6A) is a member of the actin-related protein family, serving as a key subunit of various chromatin remodeling complexes and functioning as an epigenetic regulator. It plays crucial roles in chromatin remodeling, regulation of gene expression, stem cell maintenance, cell differentiation, cell cycle progression, DNA repair, muscle regeneration, and immune system development and function. Dysregulation of ACTL6A is implicated in several cancers, contributing to tumor progression, metastasis, and poor prognosis. While no direct-acting FDA-approved drugs specifically target ACTL6A, its inhibition or knockdown has been shown to sensitize cancer cells to chemotherapy, such as temozolomide, by altering DNA repair pathways.

Other names

BAF53BAF53AINO80KArp4Baf53aSMARCN153 kDa BRG1-associated factor AINO80 complex subunit KBRG1-associated factor 53Aactin-related protein 4arpNbetahArpN beta

Inhibition or knockdown of ACTL6A sensitizes cancer cells to chemotherapy (e.g., temozolomide) by altering DNA repair pathways. It also modulates chromatin accessibility and regulates key transcriptional, cell cycle, and anti-apoptotic genes.