Actin-like protein AlpC (AlpC)

AlpC is a bacterial actin-like protein primarily identified in species such as Bacillus subtilis and certain pathogenic bacteria, where it plays a critical role in the stable inheritance of low-copy-number plasmids. It functions by polymerizing into dynamic filaments that physically push or pull plasmid DNA to opposite poles of the cell during division, a process driven by ATP hydrolysis. Because AlpC is essential for the maintenance of plasmids that often carry virulence factors and antibiotic resistance genes, it is considered an emerging target for novel antimicrobial strategies. Disrupting AlpC polymerization or its interaction with adapter proteins like AlpR can lead to plasmid loss, thereby reducing bacterial pathogenicity and reversing drug resistance. While no clinical drugs currently target AlpC, its distinct structural differences from eukaryotic actin make it a viable candidate for selective inhibition.

Other names

Actin-like protein CAlp7AAlfA-like proteinBacterial actin homolog

Inhibition of filament polymerization or ATP-binding pocket disruption to prevent plasmid inheritance and bacterial fitness.