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Actin Modulator
- Molecular classification
- Protein, Enzyme, Other
01
Overview
An actin modulator refers to any molecule, protein, or compound that influences the dynamics of actin filaments within cells. Actin is a highly conserved and abundant protein that forms microfilaments, which are essential components of the cytoskeleton in eukaryotic cells. Modulators can affect actin polymerization, depolymerization, organization, stability, and interactions with other proteins. Dysregulation of actin modulation is implicated in cancer metastasis, neurodegenerative diseases and immune dysfunctions. Acting on these pathways offers potential therapeutic strategies for cancer metastasis inhibition or immune modulation. Some drugs/toxins target specific steps in the polymerization cycle.
02
Mechanism of action
Regulates assembly/disassembly/dynamics of cellular/muscle/nuclear/cytoskeletal actins; Binds/interacts with G-/F-actins; alters polymer stability; mediates post-translational modifications
03
Biological functions
Cytoskeletal remodelingCell migrationCell divisionGene expressionOrganelle transportImmune responseCell motility
04
Disease associations
Cancer progressionCancer metastasisNeurodegenerative diseaseImmune disorders
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