Actin pseudogene

Actin pseudogene (ENSG00000230080) is classified as a pseudogene based on genome annotation sources. It does not encode a functional protein and is not expressed as a typical gene product. Pseudogenes are DNA sequences resembling genes but are generally non-functional due to mutations, deletions, or lack of proper regulatory elements. This particular pseudogene shows high sequence homology to protein-coding actin genes but does not contribute to actin protein synthesis. It is not implicated in any biological pathways, diseases, or considered a drug target. Notably, the presence of many actin pseudogenes in the human genome complicates the use of actin (ACTB) as a housekeeping reference gene in molecular assays due to potential mis-priming and amplification artifacts[1][2][5].

Other names

Actin pseudogene