Target intelligence / Profile preview

Actin-related protein 1B (ACTR1B)

Target: ACTR1B
Molecular classification: Actin family protein, Structural protein, Dynactin complex subunit

Overview

Actin-related protein 1B (ACTR1B), also known as beta-centractin, is a 42.3 kDa subunit of the dynactin complex, which is essential for microtubule-based vesicle motility. As part of dynactin, it binds microtubules and cytoplasmic dynein, and is involved in ER-to-Golgi transport, lysosome and endosome positioning, spindle formation, chromosome movement, nuclear placement, and axonogenesis. ACTR1B and its paralog ACTR1A share high sequence identity and perform similar functions. There is currently no evidence for ACTR1B being a direct therapeutic target, nor are there known interacting drugs or biomarker applications.

Other names: Beta-centractinACTR1BCTRN2ARP1BArp1BActin-related protein 1BCentractin betaPC3ARP1 actin-related protein 1 homolog B

Mechanism of action

Not applicable.

Biological functions

Microtubule-based vesicle motilityER-to-Golgi transportLysosome and endosome motilitySpindle formation and chromosome movementNuclear positioningAxonogenesis

Disease associations

There are no well-established direct disease roles for ACTR1B; dysfunction of dynactin complex has been broadly implicated in neurodegeneration, but ACTR1B-specific links are not prominent in available literature.

Safety considerations

None known specifically for therapeutic targeting. Its role as a structural and motility protein means that disruption could impact core cellular transport, yielding broad and severe cellular dysfunction, but this is not normally a therapeutic concern.

Interacting drugs

None known.

Biomarkers

None established.

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