Target intelligence / Profile preview

Actin-related protein 6 (ARP6)

Target: ARP6
Molecular classification: Actin-related protein (ARP family), Nuclear protein, Chromatin remodeling complex component (SRCAP complex)

Overview

Actin-related protein 6 (ARP6; encoded by the ACTR6 gene) is a nuclear actin superfamily member that participates in chromatin remodeling, nucleolus organization, and regulation of ribosomal DNA transcription. ARP6 is a component of the SRCAP chromatin remodeling complex, which is essential for depositing the histone variant H2A.Z in chromatin and thereby influences nucleolar morphology and gene expression. ARP6 shows dynamic, pleiotropic roles under metabolic stress and is required for ribosomal gene regulation and cell survival. While it is a critical nuclear protein for chromosome architecture and cellular homeostasis, there is no evidence to date supporting its use as a therapeutic target, biomarker, or drug-interaction partner.

Other names: ACTR6ARP6CDA12hArp6FLJ13433hARPXHSPC281MSTP136actin-related protein 6ARP6 actin related protein 6 homolog

Biological functions

Nucleolus organizationNucleosome bindingRegulation of ribosomal DNA transcriptionChromatin remodelingHistone variant deposition (H2A.Z)Metabolic homeostasisCell survival under stress

Disease associations

3-Methylcrotonyl-CoA carboxylase deficiency (listed as associated in genetic databases, but no established mechanistic role)Potentially involved in diseases with altered ribosomal function or chromatin remodeling, but no direct disease implications established

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