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Target intelligence / Profile preview
Activated Cdc42-associated kinase (None)
- Target
- None
- Molecular classification
- Enzyme, Non-receptor tyrosine-protein kinase, Serine/threonine-protein kinase
01
Overview
Activated Cdc42-associated kinase (ACK), also known as ACK1 or TNK2, is a non-receptor tyrosine kinase that acts as an effector for the small GTPase Cdc42. It plays a significant role in transducing extracellular signals to cytosolic and nuclear effectors, impacting various cellular processes such as cell spreading, migration, survival, growth, and proliferation. ACK's dysregulation is implicated in various cancers, making it a potential therapeutic target.
- Other names
- ACK1TNK2
02
Mechanism of action
Tyrosine kinase inhibition (potential)
03
Biological functions
Signal transductionCell spreadingCell migrationCell survivalCell growthCell proliferationRegulation of protein homeostasisClathrin-mediated endocytosisSynaptic function/plasticityBrain development
04
Disease associations
Cancer
05
Safety considerations
Lack of specific inhibitors in clinical trialsPotential for off-target effects due to kinase family conservation
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