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Target intelligence / Profile preview
Activated CDC42-associated kinase 1 (ACK1)
- Target
- ACK1
- Molecular classification
- Non-receptor tyrosine kinase, Enzyme, Kinase, Ack family of kinases
01
Overview
ACK1 is a non-receptor tyrosine kinase that acts as an intermediary signaling molecule between activated receptor tyrosine kinases and downstream effectors. It is involved in transmitting cell survival, growth, proliferation signals, regulating actin cytoskeleton dynamics, promoting internalization/downregulation of EGFR, participating in endocytosis, and cell adhesion signaling pathways. It is considered an oncogenic driver and its overactivation or dysregulation promotes cancer cell survival/proliferation/hormone resistance/radiation resistance across multiple cancers.
- Other names
- TNK2non-receptor tyrosine-protein kinase 2
02
Mechanism of action
Pharmacological inhibition is under investigation as an anti-cancer strategy.
03
Biological functions
Signal transductionCell survivalCell growthCell proliferationActin cytoskeleton regulationEndocytosisCell adhesionApoptosis
04
Disease associations
CancerProstate cancerHepatocellular carcinomaGastric tumorsGliomas
05
Safety considerations
Overactivation or dysregulation promotes cancer cell survival/proliferation/hormone resistance/radiation resistanceNo specific small-molecule inhibitors have yet reached clinical trials.
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