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Target intelligence / Profile preview
Activated leukocyte cell adhesion molecule (ALCAM)
- Target
- ALCAM
- Molecular classification
- Type I transmembrane glycoprotein, Immunoglobulin superfamily
01
Overview
Activated leukocyte cell adhesion molecule (ALCAM), also known as CD166, is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. It mediates both homophilic and heterophilic cell-cell interactions and is involved in various biological processes, including immune regulation, neural development, hematopoiesis, and cancer metastasis. ALCAM interacts with CD6 and LILRB4 to modulate T-cell activation and proliferation. It is implicated as a cancer stem cell marker and its expression correlates with enhanced invasion/metastasis in some cancers.
- Other names
- CD166 antigenMEMDSC-1/DM-GRASP/BEN (chicken)KG-CAM (rat)
02
Biological functions
Cell adhesionImmune regulationDevelopmental rolesNeural developmentHematopoiesisEndothelial biologyImmunological synapse formation
03
Disease associations
CancerMetastasis
04
Biomarkers
Cancer stem cell marker
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