Activating blood circulation to resolve stasis (ABCRS)

Activating blood circulation to resolve stasis (ABCRS) is a fundamental therapeutic principle in Traditional Chinese Medicine (TCM) used to treat Blood Stasis Syndrome, a pathological state characterized by impaired blood flow or internal hemorrhage [Pang et al., 2015, Journal of Ethnopharmacology]. It is not a single molecular target, such as a receptor or enzyme, but rather a broad pharmacological strategy aimed at improving hemorheology and inhibiting thrombosis. Modern research indicates that agents following this principle modulate multiple pathways, including those involving vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), and various platelet aggregation factors [Chen et al., 2011, Evidence-Based Complementary and Alternative Medicine]. Clinically, this approach is applied to treat conditions like coronary heart disease, ischemic stroke, and chronic inflammatory disorders where microcirculation is compromised [Li et al., 2019, Chinese Journal of Integrative Medicine]. Because it encompasses a wide range of biological activities and multiple molecular interactions, it is classified as a therapeutic category rather than a discrete molecular target.

Other names

Huoxue HuayuPromoting blood circulation and removing blood stasisInvigorating blood and transforming stasisActivating blood and resolving stasis

The mechanism involves a multi-target pharmacological approach including the inhibition of platelet activation and aggregation (e.g., via thromboxane B2 inhibition), modulation of the coagulation cascade, enhancement of fibrinolytic activity (e.g., increasing t-PA), and the improvement of vascular endothelial function to promote vasodilation and reduce blood viscosity [Wang et al., 2017, Frontiers in Pharmacology; Liao et al., 2014, Journal of Cardiovascular Pharmacology].