Activating signal cointegrator 1 complex subunit 1 (ASCC1)

Activating signal cointegrator 1 complex subunit 1 (ASCC1) is a nuclear protein encoded by the ASCC1 gene. It is a subunit of the ASC-1 transcriptional coactivator complex, which interacts with transcription factors and nuclear receptors to regulate tissue-specific gene transcription. ASCC1 is also part of the DNA damage response ASCC complex, playing a pivotal role in DNA repair mechanisms. It enhances NF-kappa-B, SRF, and AP-1 transactivation and is implicated in the induction of certain genes (e.g., SERPINB2) in response to signaling cues. ASCC1 is highly expressed in the central nervous system and other tissues during development, and its loss-of-function is associated with severe congenital neuromuscular syndromes, including prenatal spinal muscular atrophy and multiple congenital contractures[1][2][6].

Other names

ASCC1CGI-18ASC1p50p50ASC-1 complex subunit p50Trip4 complex subunit p50SMABF2Em:AC022392.3