Activating signal cointegrator 1 complex subunit 3 (ASCC3)

Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a large, versatile Ski2-like helicase that forms the core of the activating signal cointegrator 1 complex (ASCC), a multi-protein assembly critically involved in DNA repair, gene expression modulation, and ribosome quality control[1][2][3][4]. ASCC3 unwinds nucleic acids in a 3'-to-5' direction and is essential for generating single-stranded DNA regions necessary for alkylation damage repair by the enzyme ALKBH3[2][3]. It possesses two helicase "cassettes" capable of threading both DNA and, potentially, RNA substrates. ASCC3 also participates in cellular recovery following DNA damage and regulates the expression of interferon-stimulated genes, acting as a modulator of innate immune responses[3]. Mutations, particularly those found in cancer, often target evolutionarily conserved surfaces critical for ASCC3's function and its protein-protein interactions[2][4]. No direct drug modulators or established clinical biomarkers for ASCC3 have been reported to date.

Other names

HELIC1RQT2ASC1p200RNAHdJ121G13.4dJ467N11.1ASC-1 complex subunit p200Helicase, ATP binding 1Trip4 complex subunit p200RNA helicase familyMRT81