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Activating Transcription Factor 3 (ATF3)
- Target
- ATF3
- Molecular classification
- Transcription factor, bZIP protein, CREB family
01
Overview
Activating transcription factor 3 (ATF3) is a stress-inducible transcription factor belonging to the ATF/CREB family. It plays critical roles in regulating cellular responses to various forms of stress, including metabolism, immunity, oncogenesis, and tissue regeneration. It can act as both a transcriptional repressor and activator, depending on its dimerization partners and promoter context.
- Other names
- ATF-3LRF1LZIP
02
Mechanism of action
ATF3 acts as a transcriptional repressor or activator depending on dimerization partners and promoter context. It binds to CRE elements and regulates the expression of target genes involved in stress response, cell growth, immunity, and metabolism.
03
Biological functions
Cell growthApoptosis regulationImmune response modulationMetabolic regulationNerve regeneration
04
Disease associations
CancerFibrosisMetabolic disordersImmune disordersNervous system injury
05
Safety considerations
Potential for off-target effects due to broad regulatory functionsComplex role in cancer, with both tumor-suppressing and promoting effects
06
Biomarkers
Nerve regeneration markerPotential biomarker for cancer progression
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