Activating transcription factor 5 (ATF5)

Activating transcription factor 5 (ATF5) is a member of the basic leucine zipper (bZip) family of transcription factors within the cAMP response element-binding protein lineage. ATF5 regulates gene expression in response to cellular stress and is involved in the control of cell survival, apoptosis, cell cycle, and differentiation, particularly within the central nervous system and in developing neural tissues. It is upregulated in a variety of cancers, where it promotes tumor growth and survival, and is implicated in oncogenesis and resistance to apoptosis. Targeting ATF5 with dominant-negative peptides has shown preclinical efficacy in inducing tumor regression, highlighting its potential as a therapeutic target in oncology. ATF5 also has roles in mitochondrial homeostasis, the unfolded protein response, and maintenance of centrosome integrity during cell division, linking its activity to genome stability and cancer biology.

Other names

ATF5ATF-5

Inhibition of ATF5's pro-survival transcriptional activity, leading to tumor regression and apoptosis in cancer cells