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Target intelligence / Profile preview
Activating transcription factor 7 (ATF7)
- Target
- ATF7
- Molecular classification
- Transcription factor, Chromatin regulator, bZIP family protein
01
Overview
Activating transcription factor 7 (ATF7) is a stress-responsive transcription factor of the bZIP family encoded by the ATF7 gene on chromosome 12q13.13. It regulates gene expression by functioning as both a repressor and activator, binding to cAMP response elements in DNA, and modulating chromatin structure through recruitment of histone methyltransferases or coactivators. ATF7 plays broad regulatory roles in cell differentiation, innate immune memory, telomerase activity, and epithelial regeneration. It acts through phosphorylation-dependent mechanisms in response to cellular stress and signaling molecules such as TNF-alpha, influencing gene silencing or activation accordingly. ATF7 has been identified as a biomarker in colorectal cancer and is implicated in the pathogenesis of several infectious and dermatological diseases[1][3][8].
- Other names
- Cyclic AMP-dependent transcription factor ATF-7ATFAcAMP-dependent transcription factor ATF-7Transcription factor ATF-Atranscription factor ATF-A
02
Mechanism of action
Transcriptional modulation (activation or repression) via DNA binding and recruitment/release of chromatin-modifying enzymes (histone methyltransferases and acetyltransferases)
03
Biological functions
Regulation of transcription by RNA polymerase IIDNA-binding transcription repressor activityDNA-binding transcription activator activityChromatin remodeling/heterochromatin formationRegulation of stress responseRegulation of adipocyte differentiationRegulation of innate immune memoryTelomerase regulationMaintenance of epithelial regenerative capacity
04
Disease associations
Cancer (biomarker for colorectal cancer)Infectious disease susceptibility (e.g., Penicilliosis)Skin disease (e.g., Tinea favosa)Potential roles in inflammation
05
Safety considerations
No direct safety concerns noted in the search results; as a nuclear transcription factor, off-target modulation could theoretically impact cell survival, differentiation, or stress response pathways, but this is inferred rather than specifically reported.
06
Interacting drugs
Pseudoephedrine (reported as an inhibitor with unspecified mechanism)
07
Biomarkers
Biomarker of colorectal cancer
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