Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1)

Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) is a co-chaperone protein that binds and stimulates the ATPase activity of Hsp90, a vital molecular chaperone involved in protein folding, maturation, and trafficking[1][4][5]. AHSA1 modulates conformational dynamics at the dimer interface of Hsp90, impacting the “dwell time” of client proteins and regulating critical cellular functions, including kinase activation, signal transduction, and protein quality control[1][4][5][7]. Dysregulation or altered expression of AHSA1 is associated with cancer progression, neurodegenerative diseases, and other conditions hallmarked by aberrant protein folding[3][4]. While no drugs directly target AHSA1 yet, it is considered a promising therapeutic target due to its regulatory role in Hsp90-dependent processes[1][4].

Other names

AHA1C14orf3HSPC322p38hAha1activator of HSP90 ATPase activity 1activator of heat shock 90 kDa protein ATPase homolog 1

Small molecules or biologics that inhibit AHSA1 would reduce Hsp90 ATPase activation, impairing chaperone function and destabilizing oncogenic or misfolded proteins\nAntisense or RNAi knockdown reduces protein folding and trafficking of mutant client proteins (e.g., CFTR, tau)