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Activator of basal transcription 1 (ABT1)
- Target
- ABT1
- Molecular classification
- Transcription factor, TATA-binding protein-binding protein, basal transcriptional activator
01
Overview
Activator of basal transcription 1 (ABT1) is a nuclear protein that binds to the TATA-binding protein (TBP) and enhances basal transcriptional activity from class II promoters by promoting assembly or activation of transcription complexes for RNA polymerase II[1][2][8]. ABT1 is conserved across species (protein homologs in mouse, yeast, and C. elegans), and in yeast, its ortholog is essential for growth, indicating a fundamental role in basal gene expression[1]. The protein participates in transcriptional regulation but is not currently considered a direct therapeutic target, and its involvement in disease is limited to rare mendelian disorders[2][3][8].
- Other names
- ABT1hABT1Esf2Basal transcriptional activatorTATA-binding protein-binding proteinbasal transcriptional activator
02
Mechanism of action
Not applicable; ABT1 is not a known drug target, so mechanisms of drug action are not described for this protein
03
Biological functions
Transcriptional activation (stimulates basal transcription of RNA polymerase II-dependent class II genes by interaction with TBP)Regulation of transcriptionRNA binding (Gene Ontology annotation)Involvement in ribosomal small subunit biogenesis (predicted)
04
Disease associations
Autosomal recessive distal hereditary motor neuronopathyDistal hereditary motor neuronopathy, autosomal recessive 1Other roles in disease remain unclear and are not extensively documented.
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