Target intelligence / Profile preview

Activator of G-protein signaling 8 (AGS8)

Target: AGS8
Molecular classification: Accessory protein, G protein regulator

Overview

Activator of G-protein signaling 8 (AGS8), also known as FNDC1, is a receptor-independent accessory protein that modulates heterotrimeric G protein signaling by directly interacting with the Gβγ subunit. AGS8 is upregulated in response to hypoxic or ischemic stress, particularly in cardiovascular tissues. It regulates cell survival and angiogenesis.

Other names: FNDC1

Mechanism of action

AGS8 modulates heterotrimeric G protein signaling by directly interacting with the Gβγ subunit, influencing downstream signaling pathways without requiring nucleotide exchange on the α-subunit.

Biological functions

Signal transductionApoptosis regulationAngiogenesis regulationModulation of G protein signaling

Disease associations

Ischemia/reperfusion injuryCardiovascular diseaseCancer (angiogenesis-related)

Safety considerations

Potential for off-target effects due to broad G protein signaling modulation

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