Activator of G-protein signaling 8 (AGS8)

Activator of G-protein signaling 8 Overview

Activator of G-protein signaling 8 (AGS8), also known as FNDC1, is a receptor-independent accessory protein that modulates heterotrimeric G protein signaling by directly interacting with the Gβγ subunit. AGS8 is upregulated in response to hypoxic or ischemic stress, particularly in cardiovascular tissues. It regulates cell survival and angiogenesis.

Mechanism of Action

AGS8 modulates heterotrimeric G protein signaling by directly interacting with the Gβγ subunit, influencing downstream signaling pathways without requiring nucleotide exchange on the α-subunit.

Biological Functions

Safety Considerations