Active regulator of SIRT1 (RPS19BP1 (also known as AROS))

Active regulator of SIRT1 (AROS), also known as RPS19 binding protein 1 (RPS19BP1), is a nuclear protein that functions as a regulator of the NAD⁺-dependent deacetylase SIRT1 by binding directly to SIRT1 outside its catalytic domain and promoting SIRT1’s deacetylase activity[1][2]. AROS modulates downstream SIRT1 targets, especially p53, affecting its acetylation and thereby regulating cell survival, stress response, and apoptosis, particularly in cancer cells[2][3]. It also interacts directly with ribosomal protein S19 and participates in 40S ribosomal subunit biogenesis, further connecting ribosome assembly and protein translation to cell growth and survival processes[3]. AROS’s cancer-specific functions make it a potential target for therapeutic exploration, though it is not yet targeted by any approved drugs[2]. Its role is complex and context-dependent, contributing variably depending on cell type and stress status, particularly with respect to the SIRT1-p53 axis and ribosome function[2][3].

Other names

RPS19 binding protein 1AROSRPS19BP1S19BPFLJ21770MGC5201040S ribosomal protein S19-binding protein 1

Enhances SIRT1 deacetylase activity by direct binding, Suppresses p53 acetylation in some cell contexts via SIRT1, Promotes cancer cell survival independently of p53 under certain conditions[2][3].