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Target intelligence / Profile preview
Activin (ACT)
- Target
- ACT
- Molecular classification
- Growth factor, TGF-beta superfamily member, Dimeric protein, Cytokine
01
Overview
Activins are dimeric proteins belonging to the TGF-β superfamily, crucial for regulating various processes including embryonic development, cell proliferation and differentiation, immune responses, and reproductive system function. They signal through type II and type I serine/threonine kinase receptors, activating SMAD transcription factors. Activin activity is tightly controlled by inhibitors like follistatin.
- Other names
- Activin AActivin BActivin ABActivin CActivin EActivin AC
02
Mechanism of action
Activin binds to type II receptors (ActRIIA/B), which then recruit and phosphorylate type I receptors (ALK4/ALK7). Activated type I receptors phosphorylate SMAD2/SMAD3 proteins, leading to gene transcription.
03
Biological functions
Regulation of FSH biosynthesis/secretionEmbryonic patterning/developmentMesoderm inductionNeural developmentCell proliferationCell differentiationImmune response modulationWound healingHomeostasis maintenance
04
Disease associations
Cancer progressionInflammationFibrosisReproductive disorders
05
Safety considerations
Dysregulation linked to cancer progressionDysregulation linked to inflammationDysregulation linked to fibrosisDysregulation linked to reproductive disorders
06
Biomarkers
Activin A (potential biomarker candidate)
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