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Target intelligence / Profile preview
Activin A (ActA)
- Target
- ActA
- Molecular classification
- Growth Factor, Cytokine, TGF-beta superfamily ligand
01
Overview
Activin A is a homodimeric protein belonging to the TGF-β superfamily. It plays diverse roles in hormone regulation, tissue morphogenesis, inflammation, and neural/reproductive roles. It signals through ActRIIA/ActRIIB receptors, leading to Smad-dependent transcriptional regulation. Its activity is regulated by inhibins and other factors.
- Other names
- INHBA homodimerBeta-A Activin
02
Mechanism of action
Activin A binds to ActRIIA/ActRIIB receptors, which then recruit ALK4/ActRIB, leading to Smad-dependent transcriptional regulation.
03
Biological functions
Hormone regulationFollicle-stimulating hormone (FSH) secretionGonadal hormone secretionGerm cell development and maturationErythroid differentiationInsulin secretionNerve cell survivalEmbryonic axial developmentBone growthTissue morphogenesisTissue repairInflammationHematopoiesisCell proliferationCell differentiation
04
Disease associations
FibrosisInflammationReproductive system dysfunctionCarcinogenesisTumor biologyAnemia
05
Safety considerations
Potential for off-target effects due to widespread expression and pleiotropic functions.Careful titration required to avoid disrupting homeostatic processes.
06
Interacting drugs
Follistatin
1 more in the full profile.
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