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Target intelligence / Profile preview
Activin A Receptor Type 1C (ACVR1C)
- Target
- ACVR1C
- Molecular classification
- TGF-beta type I receptor, Serine/threonine kinase, Receptor
01
Overview
Activin A Receptor Type 1C (ACVR1C), also known as ALK7, is a type I receptor for the TGF-β superfamily. Upon ligand binding (e.g., activin A, Nodal), it phosphorylates SMAD2/3, leading to gene expression regulation. It plays a role in metabolic homeostasis, apoptosis, and cell proliferation, and is implicated in diseases such as obesity, diabetes, and cancer. Its function in cancer can be pro- or anti-tumorigenic depending on the cellular context. SB-431542 is a small molecule inhibitor of ACVR1C.
- Other names
- ALK7ACVRLK7
02
Mechanism of action
Inhibition of ALK7/ACVR1C kinase activity
03
Biological functions
Signal transductionMetabolic homeostasis regulationApoptosisCell proliferationGene expression regulation
04
Disease associations
ObesityDiabetes mellitus type IIMetabolic syndromeCancer (context-dependent)
05
Interacting drugs
SB-431542
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