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Target intelligence / Profile preview
Activin A Receptor Type 2A (ACVR2A)
- Target
- ACVR2A
- Molecular classification
- Receptor, Transmembrane serine/threonine kinase receptor, TGF-beta superfamily receptor, Activin type II receptor, Protein kinase superfamily (TKL Ser/Thr protein kinases)
01
Overview
Activin A Receptor Type 2A (ACVR2A) is a transmembrane serine/threonine kinase receptor belonging to the TGF-beta superfamily. It mediates signaling for activins and plays a key role in growth, cell differentiation, homeostasis, osteogenesis, and apoptosis. It acts as a myostatin receptor in muscle biology and is implicated in various diseases including cancer.
- Other names
- ACTR-IIAACTRIIAACVR2
02
Mechanism of action
Ligand binding leads to dimerization with type I receptors, phosphorylation and activation of type I receptors, which then activate SMAD transcriptional regulators for downstream signaling, leading to gene expression changes.
03
Biological functions
Growth regulationCell differentiationHomeostasisOsteogenesis (bone formation)ApoptosisMesoderm inductionNeural cell differentiationBone remodelingHematopoiesis (blood cell formation)Myoblast proliferation/differentiation
04
Disease associations
CancerInflammationMuscle wasting conditions (e.g., cachexia)Bone metabolism disordersAdipogenesisCarcinogenesis
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