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Activin A Receptor Type IB (ACVR1B)

Target: ACVR1B
Molecular classification: Receptor, Transmembrane serine/threonine kinase, TGF-β receptor

Overview

ACVR1B encodes the activin A receptor type IB, a transmembrane serine/threonine kinase that is part of the transforming growth factor-beta (TGF-β) superfamily. It functions as a key signal transducer for activins and related ligands. Upon ligand binding, ACVR2A or ACVR2B first bind the ligand, recruiting and phosphorylating ACVR1B, which then phosphorylates SMAD2/SMAD3 proteins to regulate gene transcription. ACVR1B plays roles in neuronal differentiation, hair follicle development, FSH production, wound healing, immunosuppression and carcinogenesis. Alterations or dysregulation of ACVR1B are implicated in various physiological processes including immune function modulation and carcinogenesis.

Other names: ALK-4Activin receptor type-1B

Mechanism of action

Kinase inhibition; modulation of SMAD signaling pathway

Biological functions

Signal transductionNeuronal differentiation and survivalHair follicle development/cyclingFSH production by pituitary glandWound healingExtracellular matrix productionImmunosuppressionMonocyte/macrophage differentiationGene transcription regulation

Disease associations

CancerReproductive disordersNeurodegenerative disordersImmune disorders

Safety considerations

Potential for off-target effects due to involvement in multiple signaling pathwaysPotential for developmental toxicity

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