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Target intelligence / Profile preview
Activin B (INHBB)
- Target
- INHBB
- Molecular classification
- TGF-beta superfamily, Growth factor, Cytokine
01
Overview
Activin B is a dimeric protein belonging to the TGF-β superfamily, composed of two βB subunits. It regulates diverse biological processes, including embryogenesis, bone remodeling, hematopoiesis, and reproductive physiology. It signals through type II and type I activin receptors, activating Smad proteins and modulating gene transcription. Recent research indicates its role in promoting liver fibrosis via hepatic stellate cell activation, making it a potential therapeutic target for fibrotic diseases.
02
Mechanism of action
TGF-beta signaling via ActRIIA/ActRIIB and ActRIA/ALK4 or ActRIB/ALK7 receptors, leading to Smad2/Smad3 phosphorylation and downstream gene transcription.
03
Biological functions
EmbryogenesisBone remodelingHematopoiesisReproductive physiologyNeural differentiationMesoderm inductionCell proliferationRegulation of FSH release
04
Disease associations
Liver fibrosisCancerFibrotic diseases
05
Safety considerations
Potential for off-target effects due to broad involvement in TGF-beta signaling.Dysregulation can lead to pathological conditions such as liver fibrosis.
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