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Target intelligence / Profile preview
Activin Receptor (ActR)
- Target
- ActR
- Molecular classification
- Receptor, Transmembrane serine/threonine kinase receptor, Transforming growth factor-beta (TGF-β) receptor family
01
Overview
Activin receptors are transmembrane serine/threonine kinase receptors that bind activins, members of the TGF-β superfamily. They mediate cellular responses including cell growth, differentiation, apoptosis, and development. The receptors form heterotetrameric complexes, activating SMAD signaling pathways to regulate gene transcription. Dysregulation is implicated in various diseases.
- Other names
- Activin receptor type IActivin receptor type IIACVR1B (ALK4)ACVR1C (ALK7)ACVR2AACVR2BBMPR2Activin receptor-like kinases (ALKs)
02
Mechanism of action
Activin receptors form heterotetrameric complexes upon ligand binding, leading to phosphorylation of SMAD proteins and subsequent regulation of gene transcription.
03
Biological functions
Signal transductionCell growth regulationCell differentiationApoptosisEmbryonic developmentEndocrine function (FSH regulation)
04
Disease associations
CancerFibrosisReproductive disordersMetabolic syndromes
05
Safety considerations
Dysregulation implicated in various diseasesPotential for off-target effects when modulating TGF-β signaling
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