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Target intelligence / Profile preview
Activin receptor-like kinase 1 (ALK1)
- Target
- ALK1
- Molecular classification
- Type I serine/threonine protein kinase, Receptor, TGF-beta superfamily receptor
01
Overview
Activin receptor-like kinase 1 (ALK1), also known as ACVRL1, is a type I cell-surface receptor serine/threonine kinase of the TGF-beta superfamily. Primarily expressed in vascular endothelial cells, it plays a critical role in angiogenesis, lymphatic vessel formation, and endothelial cell behavior. ALK1 primarily signals via Smad 1/5/9 in response to BMP9 and BMP10. Mutations or dysregulation of ALK1 are associated with hereditary hemorrhagic telangiectasia type 2, pulmonary arteriovenous malformations, and pulmonary arterial hypertension.
- Other names
- ACVRL1
02
Biological functions
AngiogenesisLymphatic vessel formationEndothelial cell proliferationEndothelial cell differentiationRecruitment of pericytes to blood vesselsSignal transduction
03
Disease associations
Hereditary hemorrhagic telangiectasia type 2 (HHT2/Rendu–Osler–Weber syndrome 2)Pulmonary arteriovenous malformationsCerebral aneurysmsPulmonary arterial hypertensionAtherosclerosis
04
Safety considerations
Dysregulation can lead to abnormal vessel formation or functionInhibition may disrupt normal angiogenesis
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