Target intelligence / Profile preview

Activin Receptor-Like Kinase 7 (ALK7)

Target: ALK7
Molecular classification: Receptor, Serine/threonine kinase receptor, TGF-beta superfamily receptor, Type I receptor

Overview

Activin Receptor-Like Kinase 7 (ALK7) is a type I serine/threonine kinase receptor belonging to the TGF-β superfamily. Primarily expressed in adipose tissue, ALK7 plays a key role in metabolic regulation, inhibiting lipolysis and promoting fat accumulation. It also induces apoptosis in specific cell types, including pancreatic beta cells and trophoblasts. Targeting ALK7 is being explored as a potential therapeutic strategy for obesity, diabetes, and cancer.

Other names: ACVR1CActivin R1C

Mechanism of action

Inhibition of ALK7 kinase activity, blocking ligand binding, or neutralizing ALK7 receptor.

Biological functions

Signal transductionRegulation of lipolysisRegulation of energy balanceInduction of apoptosisRegulation of insulin secretionRegulation of cell proliferationImmunometabolic regulation

Disease associations

ObesityDiabetesPre-eclampsiaCancerMetabolic diseaseInfertility

Safety considerations

Potential impact on reproductive biology due to expression in ovarian granulosa and epithelial cells.Potential impact on pancreatic beta cell function

Interacting drugs

Neutralizing monoclonal antibodies against ALK7

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