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Target intelligence / Profile preview
Activin Receptor Type 2A (ActRIIA)
- Target
- ActRIIA
- Molecular classification
- Transmembrane serine/threonine kinase receptor, Type II receptor, TGF-beta superfamily receptor, Receptor, Enzyme
01
Overview
Activin receptor type 2A (ActRIIA) is a transmembrane serine/threonine kinase receptor that belongs to the transforming growth factor-beta (TGF-beta) superfamily. It binds activins and other ligands, initiating downstream signaling cascades involved in cell growth, differentiation, homeostasis, and apoptosis. ActRIIA plays a crucial role in bone biology and is implicated in various diseases, making it a potential therapeutic target.
- Other names
- ACVR2AACTR-IIAACVR2
02
Mechanism of action
Ligand binding, receptor activation, SMAD phosphorylation and translocation to nucleus, gene expression regulation
03
Biological functions
Growth regulationCell differentiationHomeostasisOsteogenesisApoptosisSignal transduction
04
Disease associations
Idiopathic inflammatory myopathyAcute myeloid leukemiaCancerMuscle disordersBone disorders
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