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Target intelligence / Profile preview
Activin Type II-B Receptor (ACVR2B)
- Target
- ACVR2B
- Molecular classification
- Receptor, Transmembrane serine/threonine kinase receptor, TGF-β superfamily receptor
01
Overview
The activin type II-B receptor (ACVR2B) is a transmembrane serine/threonine kinase receptor belonging to the TGF-β superfamily. It mediates signals from TGF-β family ligands, including activins and myostatin, playing a central role in regulating muscle mass and other biological processes such as cell growth, differentiation, apoptosis, homeostasis, osteogenesis, fibrosis regulation, inflammation control, and neurogenesis modulation.
- Other names
- Activin receptor type IIBActRIIBActivin receptor type 2BACTR-IIB
02
Mechanism of action
Blocking myostatin signaling pathway to stimulate muscle hypertrophy or regeneration
03
Biological functions
Signal transductionCell growthCell differentiationApoptosisHomeostasisOsteogenesisFibrosis regulationInflammation controlNeurogenesis modulationNegative regulation of skeletal muscle mass
04
Disease associations
Muscle wastingAtrophyCancerFibrosisInflammationNeurodegenerative disease
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