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Target intelligence / Profile preview
Activin Type IIB Receptor (ActR2B)
- Target
- ActR2B
- Molecular classification
- Receptor, Transmembrane serine/threonine kinase, TGF-beta superfamily
01
Overview
The activin type IIB receptor (ActR2B, also known as ACVR2B) is a transmembrane serine/threonine kinase receptor that belongs to the transforming growth factor-beta (TGF-β) superfamily. It plays a central role in mediating signals from various ligands, including activins and myostatin, which are involved in numerous physiological processes such as muscle growth regulation, cell differentiation, homeostasis, osteogenesis, apoptosis, and more. Blocking ActR2B signaling can increase skeletal muscle mass and improve functional strength in models of muscular dystrophy.
- Other names
- ACVR2BActRIIB
02
Mechanism of action
Inhibition of ActR2B signaling, blocking ligand binding and downstream SMAD activation
03
Biological functions
Signal transductionMuscle regulationCell differentiationCell growthApoptosisHomeostasisOsteogenesisNeuronal differentiationHair follicle developmentWound healingExtracellular matrix productionImmunosuppression
04
Disease associations
Muscular dystrophyCancer
05
Interacting drugs
RAP-031/ACE-031
1 more in the full profile.
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