Actomyosin ATPase

Actomyosin ATPase is the enzyme activity that arises from the interaction of myosin (most often myosin II in muscle) with actin filaments, resulting in ATP hydrolysis coupled to force generation and movement[1][3][4]. In the muscle contractile cycle, binding of ATP to the myosin head causes dissociation from actin, hydrolysis of ATP induces a conformational change in myosin (cocking), and subsequent binding to actin and release of phosphate and ADP drives the power stroke and filament sliding[1][3]. This cycle underlies muscle contraction and many other force-generating processes in cells. Pathological alterations to actomyosin ATPase activity contribute to various muscle and cardiac diseases, and this target is pharmacologically modulated by several drugs for conditions like heart failure and hypertrophic cardiomyopathy[1][3][4].

Other names

Actin-myosin ATPaseMuscle ATPaseMyosin ATPase (when referring to actin-activated ATPase activity)

Inhibition of ATP hydrolysis (decreases contractility) Activation or sensitization of ATPase (increases contractility)