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"Acupoint stimulation" refers to the therapeutic activation of specific sites on the human body (acupoints) using techniques such as needle insertion (acupuncture), manual pressure (acupressure), electrical stimulation, heat, or laser.[1][3][4][7] These acupoints are believed in traditional Chinese medicine to influence the body's energy flow ('qi'), and in modern research, are associated with areas dense in nerve endings and connective tissue.[5] Scientific studies suggest that stimulation of these points can modulate neural, immune, and endocrine functions, mediated by activation of local nerves, endogenous opioid release, and various neurochemical pathways.[2][4][6][8] "Acupoint stimulation" is an **intervention/modality** and **not a single molecular or pharmacological target**. Key point: "Acupoint stimulation" is not a molecule/receptor/target that can be annotated in a molecular pharmacology database; it is a technique or medical approach. Entries related to proteins, receptors, or genes at acupoints (such as opioid receptors, TRPV1, purinergic receptors) would be the actual molecular targets if detailed mechanism-based annotation is required[4][6]. The term as written is too broad and does not conform to standard target entries.
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