Acyl-CoA binding domain containing 3 (ACBD3)

Acyl-CoA binding domain containing 3 (ACBD3) is a multi-functional scaffolding protein primarily localized at the Golgi complex and encoded by the human ACBD3 gene. It plays a central role in maintaining Golgi structure and function through interactions with membrane proteins such as giantin, and regulates protein transport between the endoplasmic reticulum and Golgi. ACBD3 also recruits and modulates activity of enzymes such as PI4KB, and acts as an adaptor in regulatory complexes governing steroidogenesis, lipid metabolism, and ceramide/glucosylceramide trafficking. Its interactions extend to hosting viral and bacterial protein partners, facilitating viral replication for certain positive-strand RNA viruses. In cancer, particularly non-small-cell lung cancer, ACBD3 acts as a suppressor of metastasis through NOTCH pathway inhibition. It also participates in metabolic regulation and has been implicated in disease contexts such as Huntington’s disease, infection, and metabolic syndromes. Despite diverse functions, there are no approved therapeutics or biomarkers directly targeting ACBD3 as of the latest clinical knowledge, but it represents an emerging node in cellular homeostasis and pathogen–host interactions

Other names

Golgi resident protein GCP60GCP60GOCAP1GOLPH1PAP7Golgi complex-associated protein 1Golgi phosphoprotein 1Peripheral benzodiazepine receptor-associated protein PAP7PBR- and PKA-associated protein 7PKA (RIalpha)-associated protein

Modulation of protein–protein interactions (e.g., inhibiting virus-host interactions by disrupting ACBD3–PI4KB or ACBD3–3A interactions) Regulation of enzyme localization and activity at Golgi or other organelles (e.g., PI4KB recruitment)