Acyl-CoA binding domain containing 6 (ACBD6)

ACBD6 is a lipid-binding protein containing an N-terminal acyl-CoA binding domain and two C-terminal ankyrin repeats. It selectively binds long-chain acyl-CoA species and is involved in transferring these molecules within the cell. ACBD6 directly regulates protein N-myristoylation by interacting with NMT1 and NMT2, enhancing their catalytic activity and protecting them from competitive inhibition—crucial for proper post-translational protein modification. Its expression is tissue-restricted, notably marking primitive hemangiogenic stem cells in blood and vascular tissues. ACBD6 also participates in broader cellular processes influencing stem cell maintenance, lipid metabolism, organelle architecture, and apoptosis. Although functionally significant, there are currently no drugs or therapies that directly target ACBD6, and it is not recognized as a classical receptor, enzyme, or transporter therapeutic target[1][2][4][5][6].

Other names

Acyl-CoA-binding domain-containing protein 6ACBD6MGC2404LHX4-AS1NEDPMAcyl-Coenzyme A binding domain containing 6

Not applicable There is no known therapeutic drug mechanism of action targeting ACBD6 at present.