Target intelligence / Profile preview

Acyl-CoA Cholesterol Acyltransferase 1 (ACAT1)

Target: ACAT1
Molecular classification: Enzyme, Acyltransferase

Overview

Acyl-CoA Cholesterol Acyltransferase 1 (ACAT1) is an enzyme that plays a crucial role in lipid metabolism. It catalyzes the formation of acetoacetyl-CoA from two molecules of acetyl-CoA, a key step in ketogenesis and ketolysis. ACAT1 also participates in isoleucine degradation and the esterification of cholesterol with long-chain fatty acyl CoAs to form cholesteryl esters. It is implicated in beta-ketothiolase deficiency and is a potential therapeutic target in cancer due to its role in glycolysis and tumor growth.

Other names: Acetyl-CoA acetyltransferase 1Mitochondrial acetoacetyl-CoA thiolaseT2

Mechanism of action

Inhibition of ACAT1 activity

Biological functions

KetogenesisKetolysisIsoleucine DegradationCholesterol EsterificationLipid MetabolismAcetyltransferase activity

Disease associations

Beta-ketothiolase deficiencyCancer

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