Acyl-CoA dehydrogenase family member 10 (ACAD10)

Acyl-CoA dehydrogenase family member 10 (ACAD10) is a mitochondrial enzyme belonging to the acyl-CoA dehydrogenase family, which plays a critical role in the beta-oxidation of fatty acids—particularly branched-chain substrates and 4-hydroxy acids[2][3][4][5][6]. Distinct from other acyl-CoA dehydrogenases, ACAD10 possesses an N-terminal hydrolase domain and a central serine/threonine kinase domain, along with its canonical dehydrogenase domain[2][3][6]. ACAD10 is essential for catabolizing shorter-chain 4-hydroxy acid lipids and participates in converting these molecules into intermediates compatible with mainstream mitochondrial fatty acid oxidation[3][6]. Mutations or polymorphisms in the ACAD10 gene have been associated with type 2 diabetes, insulin resistance, and certain mitochondrial disorders, suggesting a link between ACAD10 activity and metabolic disease susceptibility[2][4]. There are currently no reported specific drugs that target ACAD10, nor is it an established direct biomarker for therapy selection, though genetic variation in this gene may serve as a risk marker for certain populations[2].

Other names

ACAD10acyl-CoA dehydrogenase family member 10acyl-Coenzyme A dehydrogenase family, member 10ACAD-10MGC5601

(No mechanism established for pharmacological modulation, as no drugs targeting this enzyme are yet reported.)