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Target intelligence / Profile preview
Acyl-CoA Diacylglycerol Acyltransferase (DGAT)
- Target
- DGAT
- Molecular classification
- Enzyme, Acyltransferase, Membrane protein
01
Overview
Acyl-CoA:diacylglycerol acyltransferase (DGAT) is a microsomal enzyme that catalyzes the terminal and only committed step in triacylglycerol (TAG) synthesis, using diacylglycerol and fatty acyl CoA as substrates. This reaction is essential for the formation of TAGs, which are the primary storage form of energy in eukaryotic cells. DGAT plays a central role in lipid metabolism including intestinal fat absorption, lipoprotein assembly/secretion, adipose tissue formation/storage, lactation, and overall energy homeostasis. Pharmacological inhibition of DGAT enzymes—especially DGAT1—is being explored for treating metabolic disorders.
- Other names
- Acyl-CoA:diacylglycerol acyltransferaseDiacylglycerol acyltransferaseDGAT1DGAT2DGAT3WSDs
02
Mechanism of action
Inhibition of DGAT activity, specifically acyl-CoA binding.
03
Biological functions
Triacylglycerol biosynthesisLipid metabolismIntestinal fat absorptionLipoprotein assembly/secretionAdipose tissue formation/storageLactationEnergy homeostasis
04
Disease associations
ObesityType 2 diabetes mellitusHepatic steatosis (fatty liver)HyperlipidemiaCardiovascular disease
05
Safety considerations
Potential toxicity from DGAT inhibitors
06
Interacting drugs
T863
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