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Target intelligence / Profile preview
Acyl-CoA oxidase-like protein (ACOXL)
- Target
- ACOXL
- Molecular classification
- Enzyme, Peroxisomal protein
01
Overview
Acyl-CoA oxidase-like protein (ACOXL) is a peroxisomal enzyme encoded by the ACOXL gene on chromosome 2 in humans. It is predicted to have acyl-CoA oxidase activity, bind fatty acids, and use flavin adenine dinucleotide (FAD) as a cofactor. ACOXL is involved in the peroxisomal beta-oxidation pathway, playing a role in the breakdown of very long-chain fatty acids. It is associated with metabolic pathways and has been linked to diseases such as inflamed seborrheic keratosis and retinitis pigmentosa. Its expression and functional activity suggest potential involvement in lipid metabolism disorders and possibly cancer, but it is not currently known as a direct drug target or as the target of any approved therapies[1][2][3][6].
- Other names
- Acyl-coenzyme A oxidase-like proteinACOX4FLJ11042ACOXL
02
Biological functions
Fatty acid beta-oxidationFatty acid bindingFlavin adenine dinucleotide bindingMetabolism
03
Disease associations
CancerRetinitis pigmentosaInflamed seborrheic keratosisOther
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