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Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4)
- Target
- ACSL4
- Molecular classification
- Enzyme, Long-chain fatty-acid-coenzyme A ligase family
01
Overview
Acyl-CoA synthetase long-chain family member 4 (ACSL4) is an enzyme that converts free long-chain fatty acids into their active form, acyl-CoA esters. It plays a central role in lipid metabolism and has a strong preference for arachidonic acid. ACSL4 is involved in regulating apoptosis, eicosanoid synthesis, and is implicated in X-linked intellectual disability and potentially Alport syndrome. Recent research suggests it may be a therapeutic target for hormone-sensitive cancers like breast and prostate cancer.
- Other names
- Long-chain-fatty-acid--CoA ligase 4FACL4
02
Mechanism of action
Inhibition of fatty acid activation, reduction of steroidogenesis
03
Biological functions
Fatty acid activationLipid metabolismRegulation of apoptosisRegulation of cellular arachidonic acid levelsEicosanoid synthesisAxonal transportSynaptic development
04
Disease associations
X-linked intellectual disabilityMental retardationAlport syndrome (possible)Breast cancerProstate cancer
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