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Target intelligence / Profile preview
Acyl-CoA synthetase long-chain family member 5 (ACSL5)
- Target
- ACSL5
- Molecular classification
- Enzyme, Ligase
01
Overview
ACSL5 is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. It catalyzes the conversion of free long-chain fatty acids (C16–C20) into their active form, fatty acyl-CoA esters. This activation is essential for both lipid biosynthesis and degradation via β-oxidation. The enzyme plays a pleiotropic role in lipid metabolism depending on substrate preferences, subcellular localization, and tissue specificity.
- Other names
- ACS2ACS5FACL5
02
Mechanism of action
Catalyzes the conversion of free long-chain fatty acids into fatty acyl-CoA esters.
03
Biological functions
Lipogenesisβ-OxidationFatty acid metabolismArachidonate biosynthesisDe novo lipid synthesisFatty acid degradationMembrane modifications via protein palmitoylation
04
Disease associations
DiarrheaCancerAcute Myeloid LeukemiaColorectal CancerGlioma
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