Acyl-CoA synthetase medium-chain family member 5 (ACSM5)

Acyl-CoA synthetase medium-chain family member 5 (ACSM5) is a mitochondrial enzyme that catalyzes the activation of medium-chain fatty acids (typically C6–C10) by conjugating them with coenzyme A (CoA), forming medium-chain acyl-CoA esters in an ATP-dependent manner[1][2][5]. This reaction is essential for the metabolism of fatty acids, allowing them to enter pathways for energy production (β-oxidation), lipid synthesis, and other metabolic processes. ACSM5 is principally classified as a member of the acyl-CoA synthetase enzyme family and is encoded by the ACSM5 gene, which is expressed in humans and other mammals[2][3][5]. Dysfunction or dysregulation of ACSM5 activity has been implicated in metabolic reprogramming related to cancer progression, especially hepatocellular carcinoma, but more research is needed to define its full clinical relevance[3]. No specific drugs targeting ACSM5 are described in available sources, nor are there well-established biomarkers or safety concerns directly linked to this enzyme.

Other names

Acyl-coenzyme A synthetase ACSM5MACS3

Fatty acid thioesterification (activation of fatty acids by conversion to acyl-CoA for subsequent metabolic pathways)