Acyl-CoA thioesterase 4 (ACOT4)

Acyl-CoA thioesterase 4 (ACOT4) is a peroxisomal enzyme belonging to the Type I acyl-CoA thioesterase family, specifically catalyzing the hydrolysis of acyl-CoA esters—most notably succinyl-CoA and short- to medium-chain dicarboxylyl-CoAs—into free fatty acids and coenzyme A (CoASH)[1][2][3][5][6][7]. Highly expressed in the kidney and liver, ACOT4 performs a critical role in terminating peroxisomal beta-oxidation of dicarboxylic acids, thereby regulating lipid metabolism and preventing buildup of acyl-CoA esters in the cell. Its expression is regulated by peroxisome proliferator-activated receptor alpha (PPARα), and it may play a role in response to metabolic or stress signals vital for maintaining cellular lipid homeostasis. Disruption of ACOT4 activity impacts fatty acid metabolism, and genetic variants have been linked to increased disease risk, particularly ischemic stroke[3][5]. Although ACOT4 is not currently a direct drug target, its involvement in metabolic pathways implicates it in broader disease mechanisms where fatty acid homeostasis is disturbed.

Other names

Peroxisomal succinyl-coenzyme A thioesterasePTE2BPTEIBPTE-IbFLJ31235Acyl-coenzyme A thioesterase 4PTE-2bPeroxisomal acyl coenzyme A thioester hydrolase IbPeroxisomal long-chain acyl-CoA thioesterase IbPTE1Bperoxisomal succinyl-coenzyme A thioesteraseperoxisomal acyl coenzyme A thioester hydrolase Ibperoxisomal acyl-CoA thioesterase 2Bperoxisomal long-chain acyl-CoA thioesterase Ib

Not applicable (no known drugs directly target this enzyme)