Acyl-CoA thioesterase 7 (ACOT7)

Acyl-CoA thioesterase 7 (ACOT7) is a lipid-metabolizing enzyme predominantly expressed in the brain and some immune and cancer cells. It catalyzes the hydrolysis of long-chain acyl-CoA esters to free fatty acids and coenzyme A, regulating cellular lipid and energy metabolism. ACOT7 protects neurons from lipotoxicity, is critical for myelin development and maintenance, and has a strong role in eicosanoid (prostaglandin) metabolism. Overexpression is associated with poor prognosis in various cancers and correlates with cell proliferation and immune microenvironment modulation. In Alzheimer’s disease, elevated serum ACOT7 correlates with disease severity and is a promising noninvasive biomarker, potentially influencing amyloid precursor protein metabolism and amyloidogenic processing. Its expression patterns and regulatory impact on lipid intermediates make it a potential therapeutic target in neurodegeneration, cancer, and inflammation, though drug development may be challenged by necessary physiological functions in brain and metabolic tissues.

Other names

Cytosolic acyl coenzyme A thioester hydrolaseBACHhBACHCTE-IIACH1ACTCTE-IIaLACHLACH1MGC1126Brain acyl-CoA hydrolaseacyl-CoA thioesterase 2long chain acyl-CoA thioester hydrolase

Targeted therapies often impact proliferation/migration driven by ACOT7 overexpression; drug responsiveness may depend on ACOT7-regulated metabolic or signaling pathways in cancer. In Alzheimer’s, ACOT7 modulation influences amyloid precursor protein (APP) amyloidogenic processing