Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Acyl-CoA thioesterase 9 (ACOT9)
- Target
- ACOT9
- Molecular classification
- Enzyme, Thioesterase, Mitochondrial protein
01
Overview
Acyl-CoA thioesterase 9 (ACOT9) is a mitochondrial thioesterase enzyme encoded by the ACOT9 gene. It hydrolyzes a broad range of acyl-CoA esters, including short-, medium-, and long-chain species, thereby regulating mitochondrial levels of acyl-CoA, free fatty acids, and CoA[1][2][3][4]. ACOT9 is expressed predominantly in brown adipose tissue and kidney, and is minimally present in liver[2][3][4]. Recent studies show ACOT9 links fatty acid metabolism to amino acid metabolism, acting as a regulatory node affected by mitochondrial NADH and CoA concentrations[2][4]. Its role includes modulation of key metabolic pathways, but clinical or therapeutic drug targeting of ACOT9 has not yet been established. Dysfunction in ACOT9 is associated with lipid metabolism disorders and may impact metabolic homeostasis[6].
- Other names
- ACOT9Acyl-coenzyme A thioesterase 9, mitochondrialACATE2MT-ACT48MTACT48CGI-16Acyl-CoA thioester hydrolase 9acyl-Coenzyme A thioesterase 2, mitochondrialmitochondrial Acyl-CoA Thioesterase
02
Mechanism of action
Hydrolysis of acyl-CoA esters to generate free fatty acids and CoA
03
Biological functions
Regulation of intracellular levels of acyl-CoA, free fatty acids, and CoAHydrolysis of short-, medium-, and long-chain acyl-CoA estersMetabolic crosstalk between fatty acid and amino acid metabolismRegulation of mitochondrial metabolism
04
Disease associations
Lipid metabolism disorderSyndromic X-linked intellectual disabilityPotential roles in metabolic dysfunction (limited direct clinical evidence)
Beyond the preview
Go deeper on Acyl-CoA thioesterase 9 (ACOT9).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Acyl-CoA thioesterase 9 (ACOT9).