Acyl-coenzyme A diacylglycerol acyltransferase 2 (DGAT2)

Acyl-coenzyme A diacylglycerol acyltransferase 2 (DGAT2) is an integral membrane enzyme that catalyzes the final and committed step in triacylglycerol (TG) synthesis, acylating diacylglycerol with fatty acyl-CoA to form TG[1][2][4]. DGAT2 is primarily localized to the endoplasmic reticulum but translocates to lipid droplets under conditions of increased fatty acid availability to facilitate localized triglyceride synthesis and lipid droplet expansion[1]. The enzyme plays key roles in cellular lipid storage, energy metabolism, lipoprotein assembly, intestinal fat absorption, and adipose tissue formation[4]. Human DGAT2 is encoded by the DGAT2 gene on chromosome 11[2]. Dysfunction and altered expression of DGAT2 are implicated in metabolic disorders, especially those related to excess triglyceride storage such as obesity, hepatic steatosis, and cardiovascular disease[2]. DGAT2 is a validated therapeutic target, with several natural and synthetic inhibitors (including roselipins) identified in preclinical studies[3].

Other names

Diacylglycerol O-acyltransferase 2DGAT-2

Inhibition of triacylglycerol synthesis via blockade of DGAT2 enzymatic activity