Acyl-coenzyme A synthetase 10 (ACSL10)

Acyl-coenzyme A synthetases (ACSs) are a superfamily of enzymes that catalyze the thioesterification of free fatty acids with coenzyme A, converting fatty acids into their active acyl-CoA forms. This reaction is essential for channeling fatty acids into metabolic pathways, including β-oxidation for energy generation and biosynthesis of complex lipids. There are at least 26 mammalian ACS isoforms, with ACSL10 and the related ACSL11 belonging to the long-chain family, activating C12–C20 fatty acids. These enzymes play central roles in cellular lipid homeostasis and are implicated in a variety of diseases involving energy metabolism, including cancer, cardiovascular disease, and neurodegenerative diseases. They are considered potential therapeutic targets in these conditions due to their regulatory roles in lipid handling. The precise functions of individual isoforms (including ACSL10 and ACSL11) may vary by tissue and substrate specificity, and redundancy can complicate their biological assignment[1][2][3][4][5].

Other names

Acyl-coenzyme A synthetase family member 10Long-chain acyl-CoA synthetase 10ACSL10

Activation of free long-chain fatty acids by CoA thioesterification, committing them to anabolic (lipid synthesis) or catabolic (β-oxidation) pathways[1][3][4]. Drugs (experimental) could act as inhibitors by blocking fatty acid activation or downstream lipid metabolism.