Acyl-coenzyme A synthetase medium-chain family member 4 (ACSM4)

Acyl-coenzyme A synthetase medium-chain family member 4 (ACSM4) is a mitochondrial enzyme that catalyzes the activation of medium-chain fatty acids (typically C6-C12) by conjugation to coenzyme A (CoA), producing acyl-CoA, the first step in mitochondrial fatty acid metabolism[1][2][4][5][10][12]. This process is essential for the subsequent β-oxidation of fatty acids and overall energy homeostasis. ACSM4 is classified within the ATP-dependent AMP-binding enzyme family, with related activity enabling decanoate-CoA ligase and fatty-acyl-CoA synthase functions[1][7]. Functionally, ACSM4 is predicted to play roles in energy metabolism, particularly within tissues with significant fatty acid turnover. Pathogenic variants or altered expression of ACSM4 are associated with metabolic disorders such as Bardet-Biedl syndrome 13 and abdominal obesity-metabolic syndrome[1][2]. No drugs are currently known to specifically target ACSM4, but its involvement in acyl-CoA synthesis suggests that modulation could impact lipid metabolism–related conditions.

Other names

Acyl-coenzyme A synthetase ACSM4, mitochondrialACSM4Acsm4hACSM4Acyl-CoA synthetase medium chain family member 4P0C7M7ACSM4pMitochondrial acyl-coenzyme A synthetase ACSM4Similar to olfactory specific medium-chain acyl CoA synthetase

Enzyme activation/inhibition altering cellular fatty-acid metabolism; Potential modulation of mitochondrial fatty-acid β-oxidation