Acylphosphatase 1 (ACYP1)

Acylphosphatase 1 (ACYP1) is a small cytosolic enzyme found in vertebrate tissues, most notably in erythrocytes, where it catalyzes the hydrolysis of acylphosphates, breaking the carboxyl-phosphate bond. This enzymatic activity plays a key role in regulating glycolytic flux, membrane ion pump activity, and broader metabolic processes. ACYP1 influences multiple physiological processes including cellular differentiation, senescence, and metabolic adaptation. It is implicated in several disease states, most prominently as a prognostic biomarker of poor outcome in various cancers such as hepatocellular carcinoma, gastric cancer, and gastrointestinal tumors. Increased ACYP1 expression is associated with tumor progression, immune cell infiltration (such as Th2, Tregs, dendritic cells, macrophages), and cancer-related metabolic reprogramming. Although not presently a common direct drug target, its metabolic and immunological roles make it a candidate for therapeutic exploration in oncology and metabolic disorders[1][2][3].

Other names

Acylphosphatase-1ACYPEAcylphosphatase, erythrocyte isozymeAcylphosphate phosphohydrolase 1Acylphosphatase, organ-common type isozymeacylphosphatase-1, erythrocyte (common) type

No well-established mechanism of action for drugs specifically targeting ACYP1; role in resistance to imatinib in GIST suggests indirect modulation of drug sensitivity Broadly, inhibition or modulation could influence cancer metabolism and immune cell infiltration